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We resolved the issue by restarting the DNS service. The service did not successfully stop and we had to Kill the DNS.exe process. The service then started successfully and proper DNS and AD functionality returned.
Follow-up notes: It was later determined that the root cause was a large number of user and computer accounts (200+) all at once being added to a security group causing the Infrastruture Master to be overworked. The Directory Services log included the following events: 1)ID - 2094, Source - NTDS Replication, Description - Performance warning: replication was delayed while applying changes to the follwoing object...
2)ID - 1792Source - NTDS DatabaseDescription - A transaction lasts 39 minutes and 41 seconds, much longer thabn expected.